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5-Fluoroorotic acid

CAS No. 703-95-7

5-Fluoroorotic acid( —— )

Catalog No. M22866 CAS No. 703-95-7

5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    5-Fluoroorotic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.
  • Description
    5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    thymidylate synthase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    703-95-7
  • Formula Weight
    174.09
  • Molecular Formula
    C5H3FN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (718.02 mM; Need ultrasonic)
  • SMILES
    O=C(C(NC1=O)=C(F)C(N1)=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.P K Rathod , A Khatri, T Hubbert, W K Milhous,et al.Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.Antimicrob Agents Chemother. 1989 Jul;33(7):1090-4.
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